摘要圖檔
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標題/期刊
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作者-中心參與人員
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2020-The%20gluconeogenic%20enzyme%20PCK1%20phosphorylates%20INSIG1-2%20for%20lipogenesis_0.jpg) |
The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.
Nature, 580:530-535, 2020 Apr. |
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2022-PARG%20inhibition%20limits%20HCC%20progression%20and%20potentiates%20the%20efficacy%20of%20immune%20checkpoint%20therapy..jpg) |
PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy.
Journal of Hepatology, 77(1):140-151, 2022 Jul. |
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2021-Ribonuclease%207-driven%20activation%20of%20ROS1%20is%20a%20new%20potential%20therapeutic%20target%20in%20hepatocellular%20carcinoma..jpg) |
Ribonuclease 7-driven activation of ROS1 is a new potential therapeutic target in hepatocellular carcinoma.
Journal of Hepatology, 74(4):907-918, 2021 Apr |
許榮茂
王紹椿
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2020-PD-L1-mediated%20gasdermin%20C%20expression%20switches%20apoptosis%20to%20pyroptosis%20in%20cancer%20cells%20and%20facilitates%20tumour%20necrosis..jpg) |
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.
Nature Cell Biology, 22(10):1264-1275, 2020 Oct. |
許榮茂
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2022-Targeting%20the%20ALK-CDK9-Tyr19%20kinase%20cascade%20sensitizes%20ovarian%20and%20breast%20tumors%20to%20PARP%20inhibition%20via%20destabilization%20of%20the%20P-TEFb%20complex..jpg) |
Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex.
Nature Cancer, 3(10):1211-1227, 2022 Oct. |
張為超
山口浩史
王紹椿
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2021-TYRO3%20induces%20anti-PD-1-PD-L1%20therapy%20resistance%20by%20limiting%20innate%20immunity%20and%20tumoral%20ferroptosis..jpg) |
TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis.
Journal of Clinical Investigation, 131(8):e139434, 2021 Apr. |
山口浩史
許榮茂
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2020-Blocking%20immunosuppressive%20neutrophils%20deters%20pY696-EZH2-driven%20brain%20metastases..jpg) |
Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases.
Science Translational Medicine, 12(545):eaaz5387, 2020 May. |
張為超
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2021-LipidSig-%20a%20web-based%20tool%20for%20lipidomic%20data%20analysis..jpeg) |
LipidSig: a web-based tool for lipidomic data analysis.
Nucleic Acids Research, 49(W1):W336-W345, 2021 Jul. |
鄭維中 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2020-Three-dimensional%20two-color%20dual-particle%20tracking%20microscope%20for%20monitoring%20DNA%20conformational%20changes%20and%20nanoparticle%20landings%20on%20live%20cells..jpg) |
Three-dimensional two-color dual-particle tracking microscope for monitoring DNA conformational changes and nanoparticle landings on live cells.
ACS Nano, 14(7):7927-7939, 2020 Jul. |
劉彥良 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2023-Stem%20cell%E2%80%93nanomedicine%20system%20as%20a%20theranostic%20bio-gadolinium%20agent%20for%20targeted%20neutron%20capture%20cancer%20therapy..jpg) |
Stem cell–nanomedicine system as a theranostic bio-gadolinium agent for targeted neutron capture cancer therapy.
Nature Communications, 14(1):285, 2023 Jan. |
鄭隆賓
江智聖 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2022-MRNIP%20condensates%20promote%20DNA%20double-strand%20break%20sensing%20and%20end%20resection.%C2%A0.jpg) |
MRNIP condensates promote DNA double-strand break sensing and end resection.
Nature Communications, 13(1):2638, 2022, May. |
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2021-Glucocorticoid%20receptor%20regulates%20PD-L1%20and%20MHCI%20in%20pancreatic%20cancer%20cells%20to%20promote%20immune%20evasion%20and%20immunotherapy%20resistance.%20.jpg) |
Glucocorticoid receptor regulates PD-L1 and MHCI in pancreatic cancer cells to promote immune evasion and immunotherapy resistance.
Nature Communications, 12:7014, 2021 Dec. |
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2021-Human%20ribonuclease%201%20serves%20as%20a%20secretory%20ligand%20of%20ephrin%20A4%20receptor%20and%20induces%20breast%20tumor%20initiation..jpg) |
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation.
Nature Communications, 12(1):2788, 2021 May. |
楊文豪
王紹椿
山口浩史
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2021-Galectin-9%20interacts%20with%20PD-1%20and%20TIM-3%20to%20regulate%20T%20cell%20death%20and%20is%20a%20target%20for%20cancer%20immunotherapy.%C2%A0.jpg) |
Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy.
Nature Communications, 12:832, 2021 Feb. |
張為超
許榮茂
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2021-Structure%20and%20non-canonical%20Cdk8%20activation%20mechanism%20within%20an%20Argonaute-containing%20Mediator%20kinase%20module..jpg) |
Structure and non-canonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module.
Science Advances, 7(3):eabd4484, 2021 Jan. |
李易撰 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2022-Phosphorylation%20and%20stabilization%20of%20PD-L1%20by%20CK2%20suppresses%20dendritic%20cell%20function..jpg) |
Phosphorylation and stabilization of PD-L1 by CK2 suppresses dendritic cell function.
Cancer Research, 82(11):2185-2195, 2022 Jun. |
許榮茂
張為超
洪明奇 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2021-Homogeneous%20antibody%20and%20CAR-T%20cell%20with%20improved%20effector%20functions%20targeting%20SSEA-4%20glycan%20on%20pancreatic%20cancer..jpg) |
Homogeneous antibody and CAR-T cell with improved effector functions targeting SSEA-4 glycan on pancreatic cancer.
Proceedings of the National Academy of Sciences of the United States of America, 118 (50):e2114774118, 2021 Dec. |
林志偉 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2021-Targeting%20human%20leukocyte%20antigen%20G%20with%20chimeric%20antigen%20receptors%20of%20natural%20killer%20cells%20convert%20immunosuppression%20to%20ablate%20solid%20tumors..jpg) |
Targeting human leukocyte antigen G with chimeric antigen receptors of natural killer cells convert immunosuppression to ablate solid tumors.
Journal for ImmunoTherapy of Cancer, 9(10):e003050, 2021 Oct. |
邱紹智 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2021-Identification%20of%20theranostic%20factors%20for%20patients%20developing%20metastasis%20after%20surgery%20for%20early-stage%20lung%20adenocarcinoma..jpg) |
Identification of theranostic factors for patients developing metastasis after surgery for early-stage lung adenocarcinoma.
Theranostics, 11(8):3661-3675, 2021 Jan. |
鄭維中
黃智洋
趙坤山
佘玉萍 |
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![](/sites/rccb.cmu.edu.tw/files/imce/u70/2021-ER%CE%B1%20determines%20the%20chemoresistant%20function%20of%20mutant%20p53%20involving%20the%20switch%20between%20lincRNA-p21%20and%20DDB2%20expressions..jpg) |
ERα determines the chemoresistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions.
Molecular Therapy-Nucleic Acids, 25:536-553, 2021 Aug. |
鄭維中
劉良智
黃偉謙 |