摘要圖檔
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標題/期刊
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作者-中心參與人員
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The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. (link is external)
Nature, 580:530-535, 2020 Apr. |
洪明奇 |
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PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy. (link is external)
Journal of Hepatology, 77(1):140-151, 2022 Jul. |
洪明奇 |
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Ribonuclease 7-driven activation of ROS1 is a new potential therapeutic target in hepatocellular carcinoma.(link is external)
Journal of Hepatology, 74(4):907-918, 2021 Apr |
許榮茂
王紹椿
洪明奇 |
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PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis.(link is external)
Nature Cell Biology, 22(10):1264-1275, 2020 Oct. |
許榮茂
洪明奇 |
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Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex.(link is external)
Nature Cancer, 3(10):1211-1227, 2022 Oct. |
張為超
山口浩史
王紹椿
洪明奇 |
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TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis.(link is external)
Journal of Clinical Investigation, 131(8):e139434, 2021 Apr. |
山口浩史
許榮茂
洪明奇 |
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Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases.(link is external)
Science Translational Medicine, 12(545):eaaz5387, 2020 May. |
張為超
洪明奇 |
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LipidSig: a web-based tool for lipidomic data analysis. (link is external)
Nucleic Acids Research, 49(W1):W336-W345, 2021 Jul. |
鄭維中 |
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Three-dimensional two-color dual-particle tracking microscope for monitoring DNA conformational changes and nanoparticle landings on live cells.(link is external)
ACS Nano, 14(7):7927-7939, 2020 Jul. |
劉彥良 |
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Stem cell–nanomedicine system as a theranostic bio-gadolinium agent for targeted neutron capture cancer therapy.(link is external)
Nature Communications, 14(1):285, 2023 Jan. |
鄭隆賓
江智聖 |
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MRNIP condensates promote DNA double-strand break sensing and end resection. (link is external)
Nature Communications, 13(1):2638, 2022, May. |
洪明奇 |
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Glucocorticoid receptor regulates PD-L1 and MHCI in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. (link is external)
Nature Communications, 12:7014, 2021 Dec. |
洪明奇 |
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Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation.(link is external)
Nature Communications, 12(1):2788, 2021 May. |
楊文豪
王紹椿
山口浩史
洪明奇 |
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Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. (link is external)
Nature Communications, 12:832, 2021 Feb. |
張為超
許榮茂
洪明奇 |
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Structure and non-canonical Cdk8 activation mechanism within an Argonaute-containing Mediator kinase module. (link is external)
Science Advances, 7(3):eabd4484, 2021 Jan. |
李易撰 |
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Phosphorylation and stabilization of PD-L1 by CK2 suppresses dendritic cell function.(link is external)
Cancer Research, 82(11):2185-2195, 2022 Jun. |
許榮茂
張為超
洪明奇 |
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Homogeneous antibody and CAR-T cell with improved effector functions targeting SSEA-4 glycan on pancreatic cancer. (link is external)
Proceedings of the National Academy of Sciences of the United States of America, 118 (50):e2114774118, 2021 Dec. |
林志偉 |
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Targeting human leukocyte antigen G with chimeric antigen receptors of natural killer cells convert immunosuppression to ablate solid tumors. (link is external)
Journal for ImmunoTherapy of Cancer, 9(10):e003050, 2021 Oct. |
邱紹智 |
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Identification of theranostic factors for patients developing metastasis after surgery for early-stage lung adenocarcinoma.(link is external)
Theranostics, 11(8):3661-3675, 2021 Jan. |
鄭維中
黃智洋
趙坤山
佘玉萍 |
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ERα determines the chemoresistant function of mutant p53 involving the switch between lincRNA-p21 and DDB2 expressions.(link is external)
Molecular Therapy-Nucleic Acids, 25:536-553, 2021 Aug. |
鄭維中
劉良智
黃偉謙 |