HERO

High Endeavor Research Organization（HERO） 英雄論壇

為讓中心人才研究內容跟上國際癌症研究前沿並與世界研究接軌，本中心總主持人洪明奇院士/校長於2019年創立Higher Endeavor Research Organization（HERO），在台灣首創每周六固定舉辦 HERO Journal Club，讓所有中心研究人員透過於2小時內討論8-10最新頂尖發表的研究成果來學習相關領域的新知，發掘對中醫大研究團隊有利的切入點，進而發想具有潛力之研究計畫，並聚焦於癌症生物學及精準治療，集思廣益推展科研創新方向。不僅以有效率的方式討論目前國際研究趨勢，跟上世界研究潮流，同時也邀請本校各研究領域中對癌症有興趣的學者參與，以癌症研究與治療為出發點，團隊成員共同腦力激盪，激發創新想法，形成跨領域研究團隊。

近期報告日期/報告者

標題/期刊
2022.10.29 
12:00-14:00
Dr.  Pei-Chih Lee		 Air Pollution, Genetic Factors, and the Risk of Lung Cancer: A Prospective Study in the UK Biobank.
American Journal of Respiratory and Critical Care Medicine, 204(7):817-825, 2021 Oct.
  Gut bacteria alleviate smoking-related NASH by degrading gut nicotine.
Nature, 610(7932):562-568, 2022 Oct.
  AXL and error-prone DNA replication confer drug resistance and offer strategies to treat EGFR-mutant lung cancer.
Cancer Discovery, 12(11):2666-2683, 2022 Nov.
  Allosteric inhibition of drug resistant forms of EGFR L858R mutant NSCLC.
Nature Cancer, 3(4): 402–417, 2022 Apr.
  Anti-tumor efficacy of a potent and selective non-covalent KRASG12D inhibitor.
Nature Medicine, 28:2171–2182, 2022 Oct.
  Sublethal cytochrome c release generates drug-tolerant persister cells.
Cell, 185(18):3356-3374, 2022 Sep.
  Lymph node colonization induces tumor-immune tolerance to promote distant metastasis.
Cell, 185(11):1924-1942, 2022 May.
  Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS.
Molecular Cell, 82(11):2032-2049, 2022 Jun.
2022.11.19 
12:00-14:00
Dr. Wei-Jan Wang		 STING-induced regulatory B cells compromise NK function in cancer immunity.
Nature, 610(7931):373-380, 2022 Oct.
  cGAS-STING drives the IL-6-dependent survival of chromosomally instable cancers.
Nature, 607(7918):366-373, 2022 June.
  Spermidine activates mitochondrial trifunctional protein and improves antitumor immunity in mice.
Science, 378(6618):eabj3510, 2022 Oct.
  Immune tolerance of food is mediated by layers of CD4+ T cell dysfunction.
Nature, 607(7920):762-768, 2022 Jul.
  A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
Nature, 608(7924):778-783, 2022 Aug.
  Gasdermin D mediated release of IL 33 from senescent hepatic stellate cells promotes obesity associated hepatocellular carcinoma.
Science Immunology, 7(72):eabl7209, 2022 Jun.
  Androgen receptor blockade promotes response to BRAF/MEK-targeted therapy.
Nature, 606(7915):797-803, 2022 Jun.
  An RNA vaccine drives immunity in checkpoint-inhibitor-treated melanoma.
Nature, 585(7823):107-112, 2020 Sep.
2023.01.14
12:00-14:00
Dr. Hsiao-Fan Chen		 Dendritic cells direct circadian anti-tumor immune responses.
Nature, 614(7946):136-143, 2023 Feb.
  The circadian clock influences T cell responses to vaccination by regulating dendritic cell antigen processing.
Nature Communications, 13(1):7217, 2022 Dec.
  Synthetic cytokine circuits that drive T cells into immune-excluded tumors.
Science, 378(6625):eaba1624, 2022 Dec.
  Enhanced T cell effector activity by targeting the Mediator kinase module.
Science, 378(6620):eabn5647, 2022 Nov.
  PD-1-cis IL-2R agonism yields better effectors from stem-like CD8+ T cells.
Nature, 610(7930):161-172, 2022 Oct.
  Interleukin-6 blockade abrogates immunotherapy toxicity and promotes tumor immunity.
Cancer Cell, 40(5):509-523, 2022 May.
  Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Cancer Cell, 40(10):1111-1127, 2022 Oct.
  Clathrin-associated AP-1 controls termination of STING signaling.
Nature, 610(7933):761-767, 2022 Oct.